Laser Matter Interaction refers to the interaction between laser with different parameters and different matter under different conditions. We focus on the basic and applied basic research of femtosecond laser micro-nano structures, high-order harmonics and nonlinear optics. In the field of femtosecond laser-induced periodic surface structures (LIPSS), we have rich experience and independently set up the processing experimental conditions, such as single-beam, time-delayed double beam and vacuum low-temperature environment, which can be used to research the complex micro-nano structures, photonic crystals and nanowires on the surfaces of metals, semiconductors and dielectric materials. By using femtosecond laser to fabricate cross-scale bio-nanostructures on the material surfaces, we get metal, polymer, glass and other material surfaces that can regulate superwettability and durability. Such material surfaces have the characteristics of superhydrophobicity, anti-adhesion, anti-bacteria, anti-corrosion, self-cleaning, green and low cost, which is expected to be applied in many fields such as anti-corrosion in deep-sea, medical equipment, heat pump system, environmental protection toilets and automobile parts. In the basic research of laser matter interaction, we are also committed to exploring the generation and detection of high-order harmonics in laser ablation plasma plumes (LPPs), solids and metamaterials. As the only experimental group in China to study the generation of high-order harmonics in LPPs, we set up independently a high-vacuum HHG apparatus based on LPPs, which greatly broadening the selection of materials for HHG. In the applied basic research of laser matter interaction, we are also devoted to explore and develop new nonlinear optical devices and nonlinear optical functional surfaces. In addition, we carry out research on theoretical calculation, experimental measurement and nanoscale device design of nonlinear metasurfaces, photonic crystals and new two-dimensional materials.